Title | COMBat: Visualizing co-occurrence of annotation terms |
Publication Type | Conference Paper |
Year of Publication | 2013 |
Authors | van Brakel, RBJ, Fiers, MWEJ, Francke, C, Westenberg, MA, van de Wetering, H |
Conference Name | 2013 IEEE Symposium on Biological Data Visualization (BioVis)2013 IEEE Symposium on Biological Data Visualization (BioVis) |
Publisher | IEEE |
Conference Location | Atlanta, GA, USA |
Accession Number | 13898666 |
Keywords | Biology, cellular biophysics, computing, filtering theory, genetics, Genomics |
Abstract | We propose a visual analysis approach that employs a matrix-based visualization technique to explore relations between annotation terms in biological data sets. Our flexible framework provides various ways to form combinations of data elements, which results in a co-occurrence matrix. Each cell in this matrix stores a list of items associated with the combination of the corresponding row and column element. By re-arranging the rows and columns of this matrix, and color-coding the cell contents, patterns become visible. Our prototype tool COMBat allows users to construct a new matrix on the fly by selecting subsets of items of interest, or filtering out uninteresting ones, and it provides various additional interaction techniques. We illustrate our approach with a few case studies concerning the identification of functional links between the presence of particular genes or genomic sequences and particular cellular processes. |
URL | http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=6664342 |
DOI | 10.1109/BioVis.2013.6664342 |