TGAC Browser

We present the TGAC Browser with novel rendering, annotation and analysis capabilities designed to overcome the shortcomings in available approaches. TGAC Browser, being a web-based client, utilises JavaScript libraries to provide a fast and intuitive genome browsing experience. We focus on harnessing Internet architectures as well as localised HPC hardware, concentrating on improved, more productive interfaces and analytical capabilities.

• User-friendly: Live data searching, track modification, and drag and drop selection; actions that are seamlessly powered by modern web browser
• Responsiveness: Client-side rendering and caching, based on JSON fragments generated by server logic, helps decrease the server load and improves user experience
• TGAC Browser visualises genomic data in different ways, based on the type and amount of data, which is more informative to the user and memory efficien
• Analysis Integration: The ability to carry out heavyweight analysis tasks, using tools such as BLAST, via a dedicated extensible daemon
• Annotation: Users can edit annotations which can be persisted on the server, reloaded, and shared at a later date
• Off-the-shelf Installation: The only prerequisites are a web application container, such as Jetty or Tomcat, and a standard Ensembl database to host sequence features
• Extensible: Adaptable modular design to enable interfacing with other databases, e.g. GMOD
• Data format: TGAC Browser processes and visualises data directly from the Ensembl core schema as well as next-generation sequencing (NGS) data output, i.e. BAM/SAM, BigWig/wig, GFF, and VCF.
• Manual Annotation: Live editing of Genomics annotations within TGAC Browser, saved with versions and can be reverted, exported in Genomics data format for curator to edit datasets (Under development).

Email: Anil.Thanki@earlham.ac.uk

Source Code: https://github.com/tgac/tgacbrowser