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Exploring annotated modules in networks

Kasper Dinkla
Mohammed El-Kebir
Cristina-Iulia Bucur
Marco Siderius
Martine J Smit
Gunnar W Klau

eXamine accurately conveys small and annotated modules consisting of several dozens of proteins and annotations. We demonstrate that eXamine facilitates the interpretation of integrative network analysis results in a guided case study. This study has resulted in a novel biological insight regarding the virally-encoded G-protein coupled receptor US28.

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Kasper Dinkla is supported by the Netherlands Organisation for Scientific Research (NWO) under project no. 612.001.004.